2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8960
    1-Hydroxybisabola-2,10-dien-4-one 1213251-45-6 98%
    1-Hydroxybisabola-2,10-dien-4-one is a compound with potential anti-Alzheimer's disease activity. The activity of 1-Hydroxybisabola-2,10-dien-4-one was evaluated in the Caenorhabditis elegans Alzheimer's disease pathological model. 1-Hydroxybisabola-2,10-dien-4-one has a wide range of applications in life science related research.
    1-Hydroxybisabola-2,10-dien-4-one
  • HY-N9164
    Hecubine 62874-52-6 98%
    Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases.
    Hecubine
  • HY-N9374
    Bufotenidine 487-91-2 98%
    Bufotenidine, a natural indole alkaloid, is a blocking agent of the tryptaminic receptors.
    Bufotenidine
  • HY-N9503
    Carvacryl acetate 6380-28-5 99.80%
    Carvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na+/K+-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases.
    Carvacryl acetate
  • HY-N9554
    WIN-64821 150881-27-9 98%
    WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The Ki values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca2+ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research.
    WIN-64821
  • HY-N9861
    Kayaflavone 481-45-8 98%
    Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC50 value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease.
    Kayaflavone
  • HY-N9928
    Echinenone 432-68-8 98%
    Echinenone is an acetylcholinesterase (AChE) inhibitor (IC50=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage.
    Echinenone
  • HY-P1018
    IRL 1038 144602-02-8 98%
    IRL 1038 is an endothelin B receptor selective antagonist with a Ki of 6-11 nM.
    IRL 1038
  • HY-P1044
    Spinorphin 137201-62-8 98%
    Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect.
    Spinorphin
  • HY-P1364
    Pep1-AGL 98%
    Pep1-AGL is a peptide with the sequence of SSGMPLGAAGL. Pep1-AGL serves as the control peptide for Pep1-TGL (HY-P1367).
    Pep1-AGL
  • HY-P1400
    Neuropeptide Y (scrambled) 98%
    Neuropeptide Y (scrambled) is a scrambled peptide that serves as a negative control for Neuropeptide Y.
    Neuropeptide Y (scrambled)
  • HY-P2714
    SEVNLDAEFR 186142-28-9 98%
    SEVNLDAEFR is a substrate for BACE1.
    SEVNLDAEFR
  • HY-P3071
    ShK toxin 172450-46-3 98%
    ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation.
    ShK toxin
  • HY-P3095
    α-Latrotoxin 65988-34-3 98%
    α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals.
    α-Latrotoxin
  • HY-P4867
    β Amyloid (1-42) (scrambled) 1678415-52-5 98%
    β Amyloid (1-42) (scrambled) is a negative control of β-Amyloid (1-42), human (HY-P1363A).
    β Amyloid (1-42) (scrambled)
  • HY-P4885
    Glp-amyloid-β (3-40) peptide (human) 161818-04-8 98%
    Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice.
    Glp-amyloid-β (3-40) peptide (human)
  • HY-P5945
    β-Amyloid (1-8, A2V) 98%
    β-Amyloid (1-8, A2V) is amutantion of β-Amyloid (1-8) (HY-P5946).
    β-Amyloid (1-8, A2V)
  • HY-P5967
    Acetly-β Amyloid(15-20), Amide 189064-06-0 98%
    Acetly-β Amyloid (15-20), Amide is a peptides fragment. Acetly-β Amyloid (15-20), Amide inhibits the β-sheet formation and stabilizes structure of Aβ (1–40) peptide. Acetly-β Amyloid (15-20), Amide can be used in study Alzheimer’s disease.
    Acetly-β Amyloid(15-20), Amide
  • HY-P5968
    [Ala28]-β Amyloid(25-35) 173993-86-7 98%
    [Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electrically neutral mutant peptide of Aβ(25-35) that accelerates the aggregation of Firefly Luciferase.
    [Ala28]-β Amyloid(25-35)
  • HY-Z2493
    Aripiprazole N1-oxide 573691-09-5 98%
    Aripiprazole N-oxide is a metabolite of the atypical antipsychotic Aripiprazole (HY-14546). Aripiprazole N-oxide is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.
    Aripiprazole N1-oxide
Cat. No. Product Name / Synonyms Application Reactivity